The seeds of Nigella sativa (N.sativa) Linn. (Ranunculaceae) are used commonly in the Middle East as a traditional medicine to treat variety of health conditions and has health promoting properties. In present investigation petroleum ether (PEE) and ethanolic extract (EE) of N. sativa seeds were evaluated. On the basis of their physiochemical characters and antioxidant potential. Both extract were found to possess significant antioxidant activity against DPPH free radical. IC50 for PEE was 54.2 µg/ml and for EE was 71.2 µg/ml. Ethanolic extract was having significant quantity of phenolic and flavonoid components, this was confirmed on the basis of TPC (67.45 µg/mg extract GAE) and TFC (74 µg/mg extract RE) test. Thus from present study it can be concluded that pet ether extract and ethanolic extract of N. sativa are good antioxidants and would be a good alternative for diseases related to oxidative stress.
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